1-boc-4-AP is a precursor chemical used in the synthesis of illicit fentanyl products.
Pursuant to the final rule published on April 15, 2020,5 chemical mixtures containing 1boc-4-AP have been and continue to be subject to regulatory requirements at any concentration – unless a manufacturer submits to DEA an application for exemption of a chemical mixture, DEA accepts the application for filing, and DEA exempts the chemical mixture in accordance with 21 CFR 1310.13 (Exemption of chemical mixtures by application). Since even a small amount of 1-boc-4-AP can potentially yield a significant amount of controlled substances, DEA believes that the continued regulation of chemical mixtures containing any amount of 1-boc-4-AP as a list I chemical is necessary to prevent its illicit extraction, isolation, and use. 1-boc-4-AP is already subject to domestic control under list I as a carbamate of N-phenylpiperidin-4-amine, and DEA’s current regulations provide that a chemical mixture containing any amount of N-phenylpiperidin-4-amine is a List I chemical.