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4F-MDMB-BICA (4F-MDMB-BUTICA) is a synthetic cannabinoid that has been sold online and used to mimic the biological effects of tetrahydrocannabinol, the main psychoactive constituent in marijuana. Research and clinical reports have demonstrated that synthetic
cannabinoids are applied onto plant material so that the material may be smoked as users attempt to obtain a euphoric and psychoactive “high.” Synthetic cannabinoids have been marketed under the guise of “herbal incense,” and promoted by drug traffickers as legal alternatives to marijuana.

4F-MDMB-BICA was first identified in the United States (U.S.) in plant-like material seized by law enforcement in May 2020 and soon after in toxicology casework in July 2020, with concurrent emergence in European countries.

4F-MDMB-BICA is structurally similar to the synthetic cannabinoid 4F-MDMB-BINACA, differing by an indole vs. indazole core, respectively.

4F-MDMB-BICA is an activator of the cannabinoid receptor system and its toxicity can be demonstrated through medicolegal death investigations paired with comprehensive toxicology findings. In the U.S., 4F-MDMB-BICA has been identified in at least 26 toxicology cases associated with postmortem (PM) and driving under the influence of drugs (DUID) investigations.

In Europe, 4F-MDMB-BICA has been identified in several countries, including Hungary, the United Kingdom, Belgium, and Slovenia. Eleven deaths were attributed to the use of 4F-MDMB-BICA in Hungary between May and August 2020. (See NPS Public Alert)

There are no commercial or approved medical uses for 4F-MDMB-BICA, and it is not a controlled substance under the CSA but may be considered an analogue of other Schedule I substances.


National Association of Drug Diversion Investigators Federal Tax ID: 52-1660752 / DUNS Number: 073539913

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